RT Journal
A1 SHULLENBERGER CC, WATKINS CH, KIERLAND RR
T1 EXperiences with nitrogen mustard therapy
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1949
FD March 19
VO 139
IS 12
SP 773
OP 777
DO 10.1001/jama.1949.02900290019005
UL http://dx.doi.org/10.1001/jama.1949.02900290019005
AB Until recently, the palliative treatment of lymphoblastoma and other neoplastic diseases has depended almost entirely on the use of irradiation by roentgen rays or radium. With the recent introduction of the nitrogen mustards as potential therapeutic agents in this field, a concentrated effort has been made by various groups of investigators1 to determine whether there are any specific indications for the use of these substances in place of, or as an adjunct to, irradiation therapy. Since it appears that the biologic effects of the nitrogen mustards and the qualitative clinical response caused by them are similar to, if not identical with, those exerted by irradiation,2 and since their availability and ease of administration confer definite advantages over irradiation therapy, it becomes a matter of some importance to know what may be expected of these agents when they are employed under certain clinical conditions.Two fundamental questions are raised.