RT Journal
A1 TYLER ET
T1 USe and misuse of endocrine therapy in sterility
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1949
FD February 26
VO 139
IS 9
SP 560
OP 564
DO 10.1001/jama.1949.02900260006002
UL http://dx.doi.org/10.1001/jama.1949.02900260006002
AB With the increasing availability of potent endocrine products, these substances have had an extensive range of clinical application. However, despite advances in knowledge of the physiologic relationships of endocrines, clinical therapy has been in many circumstances a "hit and miss" affair. Notably has this been true in the field of infertility, where various of the so-called sex hormones have been employed with extremely variable results. Such variability may be ascribed, in considerable measure, to the complexities of the sterility problem and perhaps to the disproportionate attention to the hormonal factors. In this connection, it cannot be overemphasized that normal fertility in a mating entails a number of important factors, only some of which are disturbed to any clinical extent by endocrine disorders.The requisites for normal fertility in the female may be summarized as: (1) normally functioning ovaries, in which there is cyclic maturation of a graafian follicle with ovulation