RT Journal
T1 Anemia in practice: Pernicious anemia
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1939
FD September 23
VO 113
IS 13
SP 1248
OP 1248
DO 10.1001/jama.1939.02800380066032
UL http://dx.doi.org/10.1001/jama.1939.02800380066032
AB This volume represents a detailed discussion of the clinical investigations of pernicious anemia in which the author has participated during the past fifteen years. The importance of treatment in the presence of complications, particularly the neurologic, is stressed and well presented. A briefer and somewhat less comprehensive presentation of certain of the other anemic states is included, apparently for the sake of completeness. The use of liver extract in the treatment of the hemolytic anemias would seem to be somewhat uncritically and over-enthusiastically advocated in the light of the published experience from other clinics and on the basis of the known difference in the pathologic changes in the bone marrow in pernicious anemia (megaloblastic hyperplasia) and in hemolytic jaundice (normoblastic hyperplasia) and of the knowledge of the point in the erythrocyte maturation cycle at which the erythrocyte maturation factor is effective. The treatise has been written by the author that