RT Journal
A1 Dick GH
T1 CHange in medium for scarlet fever toxin
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1939
FD September 16
VO 113
IS 12
SP 1150
OP 1150
DO 10.1001/jama.1939.02800370066027
UL http://dx.doi.org/10.1001/jama.1939.02800370066027
AB To the Editor:— 
    Some persons who have received injections of diphtheria toxoid, especially the alum precipitated toxoid, may be sensitized to proteins contained in veal broth and consequently develop urticaria following injection of other veal broth preparations.To avoid the development of urticaria in such persons during the course of immunization against scarlet fever, the medium in which scarlet fever toxin is produced has been changed to one which contains no meat infusion. Use of this medium results in a toxin containing considerably less protein and a marked reduction in the incidence of urticaria.