RT Journal
T1 CUrrent comment
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1939
FD July 15
VO 113
IS 3
SP 236
OP 236
DO 10.1001/jama.1939.02800280048014
UL http://dx.doi.org/10.1001/jama.1939.02800280048014
AB A NONSPECIFIC FACTOR IN RESISTANCE 
    The relation of physical fitness to the ability to withstand infection has proved highly variable in practice, although the belief that the physical condition affects susceptibility to infection in some instances has been amply substantiated. Experimental evidence seems to indicate that several factors may be involved.1 An especially interesting contribution to this subject has been reported recently by Locke.2 For the rabbit, the experimental animal used in his experiments, fitness was approximated in terms of warming time, that is the number of minutes required for the recovery of 3 degrees of body temperature following chilling to a point between 95 and 96 F. Various factors producing circulatory impairment, including shock, the administration of morphine, exposure to overheating, deprivation of food and fatigue, were studied in relation to their effect on warming time. When animals affected by these procedures were compared with normal animals