RT Journal
A1 GRAESER JB
T1 INhalation therapy of bronchial asthma
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1939
FD April 1
VO 112
IS 13
SP 1223
OP 1226
DO 10.1001/jama.1939.02800130007003
UL http://dx.doi.org/10.1001/jama.1939.02800130007003
AB The possibility of obtaining relief of asthmatic symptoms by the direct application of a solution of epinephrine to the bronchial mucosa was reported by Ephraim1 as early as 1910. Through the bronchoscope he first observed blanching of the mucous membrane after subcutaneous administration of epinephrine. Subsequently, epinephrine solution was sprayed directly into the bronchi through the bronchoscope with definite relief of asthmatic symptoms. In a later communication Ephraim2 repeated these observations and commented on the beneficial effect of procaine hydrochloride alone, although he said that greater benefit resulted from the epinephrine. Thereafter, other authors reported the efficacy of the inhalation of epinephrine solutions for the relief of asthmatic symptoms. The earler of these were Krause,3 Segel4 and Zuelzer.5 In later years a number of reports have been made concerning this procedure, such as those of Grunwald,6 Sachse,7 Weiss and Magassy,8 Camps,9