RT Journal
T1 PRevention and treatment of atherosclerosis
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1949
FD October 8
VO 141
IS 6
SP 392
OP 393
DO 10.1001/jama.1949.02910060030010
UL http://dx.doi.org/10.1001/jama.1949.02910060030010
AB Knowledge of the factors involved in atherosclerosis, i. e., the most common type of arteriosclerosis characterized anatomically by the deposition of lipoidal matter in the arterial intima, has made significant progress recently. The clinical and experimental evidence supplies added weight to the concept that an instability of the plasma lipids of transitory or persistent nature is related to the development of these lesions. Abnormalities of the fat and oxygen metabolism represent the primary cause of these colloidal plasmatic disturbances.1After Moreton2 pointed out that the postprandial episodes of macrochylomicronemia following the intake of fatty meals might be related to atherosclerosis, Pollak3 showed that cholesterol dispersed in serum and intravenously injected into rabbits was taken up by the arterial endothelium within a few minutes after injection. Although the total amount of chylomicrons after a meal is always in direct proportion to the quantity of fat ingested, Setälä4