RT Journal T1 DIe permeabilitätspathologie als die lehre vom krankheitsbeginn JF Journal of the American Medical Association JO Journal of the American Medical Association YR 1949 FD September 17 VO 141 IS 3 SP 235 OP 235 DO 10.1001/jama.1949.02910030065040 UL http://dx.doi.org/10.1001/jama.1949.02910030065040 AB This book represents a much enlarged edition of the previously published monograph of this author on serous inflammation. Additional observations include studies with fluorescent microscopy, investigations on hepatic diseases derived from experiences during the war and studies on renal diseases. In the original publication, considerable emphasis was placed on the escape of plasma proteins into the tissue spaces and on the sequelae supposedly resulting from this escape. Much importance was attached to this serous inflammation (a name derived from Roessle) in various parenchymal organs. In the present enlarged treatise, in addition, the invasion of the parenchymal cells themselves by plasma proteins is stressed. These shifts in plasma proteins caused by altered permeability of the cellular membranes and capillaries are considered important in the pathogenesis of many diseases. Disturbances of the permeability of cellular and capillary membranes are considered the initial processes of many pathologic conditions. Morphologic and functional alterations in