RT Journal
A1 Moruzzi G
T1 BRomides, hypophysis and thyroid
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1949
FD September 17
VO 141
IS 3
SP 216
OP 217
DO 10.1001/jama.1949.02910030046021
UL http://dx.doi.org/10.1001/jama.1949.02910030046021
AB To the Editor:— 
    I have read the interesting article by Ravdin, Rose and James Maxwell, which appeared in The Journal (140:141-146 [May 14] 1949) under the heading "The Treatment of Thyrotoxicosis." With respect to the first part of that article, in which various treatments of thyrotoxicosis are dealt with, I wish to call the attention to the action of bromides (sodium bromide) on the thyroid and the hypophysis.In a group of researches (worked out from 1934 to 1943, Arch. di fisiol., 1939-1940; Boll. Soc. ital. biol. sper. 1936, 1939 and 1943; Naturwissen., 1938-1940; Riv. Svizzera di Med., 1940), my co-workers and I showed that sodium bromide when administered for a long period and in proper doses to animals (dogs, rabbits, rats) causes a remarkable decrease in the iodine content of the thyroid and, consequently, evident hypofunction of this gland. This is physiologically proved by a decrease of basal