RT Journal
A1 NEWBURGH LH, CONN JW
T1 A new interpretation of hyperglycemia in obese middleaged persons
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1939
FD January 7
VO 112
IS 1
SP 7
OP 1
DO 10.1001/jama.1939.02800010009002
UL http://dx.doi.org/10.1001/jama.1939.02800010009002
AB The term diabetes mellitus has in the past implied a single cause. Ever since the days of von Mering and Minkowski this disease has been attributed to a pancreatic abnormality. However, within the last few years the work of a number of investigators has made it clear that this conception is far too restricted. Houssay,1 for example, has shown that the rapidly fatal diabetes produced by pancreatectomy in animals may be strikingly ameliorated by subsequent hypophysectomy. In the same sense Mann2 has produced fatal hypoglycemia in depancreatized dogs by hepatectomy. A number of workers have produced hyperglycemia and glycosuria by injection of pituitary extracts, and Young3 reported that he obtained permanent "diabetes" in dogs solely as the result of prolonged injection of anterior pituitary extracts.It is therefore clear that clinical investigators must now attempt to discover the specific cause of the hyperglycemia in all patients who