RT Journal
A1 WILLIAMS GE, NOMLAND R
T1 GOnadotropic substance in the treatment of acne
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1937
FD August 21
VO 109
IS 8
SP 564
OP 565
DO 10.1001/jama.1937.02780340020007
UL http://dx.doi.org/10.1001/jama.1937.02780340020007
AB The existence of a probable endocrine dysfunction in acne has been assumed for many years. The exact nature of this dysfunction and the identification of the specific factor responsible is still a matter of research and experimentation. Clinical trial of the gonadotropic factor from pregnancy urine has given variable results according to several recent reports. In none of these series were controls run to compare the improvement in patients not receiving the gonadotropic preparation.To determine the effectiveness of gonadotropic substance from pregnancy urine (antuitrin-S) in the treatment of acne, thirty-nine students were studied. These all received the same local treatment but half were given gonadotropic substance and the half used as a control received injections of sterile water.Lawrence1 reported favorably on the use of gonadotropic substance from pregnancy urine in a study of two series of acne patients. In his opinion the gonadotropic mechanism was probably the