RT Journal
A1 Foshay L
T1 SErum treatment of tularemia
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1932
FD February 13
VO 98
IS 7
SP 552
OP 552
DO 10.1001/jama.1932.27320330001009
UL http://dx.doi.org/10.1001/jama.1932.27320330001009
AB Ten cases of acute tularemia have been treated with a specific antiserum prepared from a goat inoculated with formaldehydekilled suspensions of Pasteurella tularensis. The therapeutic responses have been sufficiently definitive to justify a preliminary report.Usually about 10 cc. of serum has been given intravenously to each patient on both the first and the second day in the hospital. No serum reactions have occurred. In nine cases there has occurred an abrupt cessation of fever, malaise, chills, sweats, arthralgias and myalgias forty-eight hours after the second injection, and also a rapid reduction in the volume of the involved lymph glands to an average of one half of their former diameters. Not a single lymph gland has suppurated. The skin rash, when present, has likewise either disappeared or faded extensively within the first three days. One patient, received in a dying condition, was not benefited.A detailed report of these and