RT Journal
A1 STURGIS CC, ISAACS R
T1 DEsiccated stomach in the treatment of pernicious anemia
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1929
FD September 7
VO 93
IS 10
SP 747
OP 749
DO 10.1001/jama.1929.02710100009004
UL http://dx.doi.org/10.1001/jama.1929.02710100009004
AB After the discovery by Minot and Murphy1 of the beneficial effects of liver therapy in pernicious anemia and the preparation of an active extract by Cohn and his associates,2 the way for further study was opened by the demonstration by Castle3 that the stomach of normal persons secreted a substance which could develop a blood-maturing principle from meat. After a consideration of these investigations, it seemed advisable to us to test the activity of gastric tissue itself. Work was started at the Simpson Memorial Institute on the nature of the material in stomach which could produce a hematopoietically active substance, but the experiments were later carried on with the association of Dr. Elwood A. Sharp, director of the department of experimental medicine of Parke, Davis and Company. Dr. Sharp, working on the basis of an original theory, concluded that the feeding of stomach should have the same