RT Journal A1 HORSLEY J T1 PEptic ulcer and cancer of the stomach JF Journal of the American Medical Association JO Journal of the American Medical Association YR 1929 FD June 1 VO 92 IS 22 SP 1813 OP 1816 DO 10.1001/jama.1929.02700480003002 UL http://dx.doi.org/10.1001/jama.1929.02700480003002 AB The etiologic relation of peptic ulcer to cancer of the stomach is acknowledged by all pathologists who have studied the subject. There is, however, a great difference of opinion as to the number of cases of cancer of the stomach due to peptic ulcer. The incidence varies from about 2 per cent, estimated by Ewing1 of New York, to more than 60 per cent by MacCarty2 of the Mayo Clinic. MacCarty says that, in about 70 per cent of the chronic gastric peptic ulcers, cells can be found that present the cytologic appearance of cancer. Though MacCarty does not state that this percentage of chronic gastric peptic ulcers would eventually become cancer, such a conclusion is suggestive. The opportunities at the Mayo Clinic for examining fresh tissue are great. According to W. J. Mayo,3 "von Eiselsberg of Vienna reported that 30 per cent of all ulcers of