RT Journal
A1 GIFFIN HZ, CONNER H
T1 THe untoward effects of treatment by phenylhydrazine hydrochloride
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1929
FD May 4
VO 92
IS 18
SP 1505
OP 1507
DO 10.1001/jama.1929.02700440013007
UL http://dx.doi.org/10.1001/jama.1929.02700440013007
AB Phenylhydrazine hydrochloride has come into general use as a therapeutic agent in the treatment of polycythemia vera. It was employed experimentally in animals in 1885 by Hoppe-Seyler.1 Morawitz and Pratt2 in 1908 used it for the purpose of producing experimental anemia in animals, and Eppinger and Kloss3 in 1918 were the first to apply it clinically in cases of polycythemia vera. The reports that have appeared in the literature since that time concerning the treatment of polycythemia vera by means of phenylhydrazine have, in the main, been very favorable. Good results have been reported by Eppinger and Kloss,3 Taschenberg,4 Levi,5 Owen,6 Brown and Giffin,7 Altnow and Carey,8 Stealy9 and Cabot.10 Bryan11 alone called attention to possible serious unfavorable effects of phenylhydrazine. In the early cases an unnecessarily severe anemia was produced and the occurrence of thrombosis was noted. The