RT Journal
A1 WINKELSTEIN A, MARCUS JM
T1 EXcretion of neutral red in the stomach in achylia gastrica
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1929
FD April 13
VO 92
IS 15
SP 1238
OP 1240
DO 10.1001/jama.1929.02700410008003
UL http://dx.doi.org/10.1001/jama.1929.02700410008003
AB In 1908, Fuld1 discovered that neutral red would appear in a Pavlov pouch after it was placed in the large stomach. Many years later, Finkelstein2 found that it was practically the only dyestuff eliminated in appreciable quantities in the Pavlov pouches of dogs. In 1923, one year later, Glaessner and Wittgenstein3 applied this fact clinically. Finding that this dyestuff was nontoxic and not irritating locally, they injected 4 cc. of a 1 per cent watery solution intramuscularly in forty patients. They found that the appearance time of the neutral red in the stomach paralleled the acidity; i. e., in normal persons it was fifteen minutes; in hyperacidity, from five to eight minutes; in subacidity, from twenty to sixty minutes; and in achylia gastrica, it did not appear. In 1925, being interested in the possibility of improving our studies of gastric function, we4 repeated this work in