RT Journal
A1 SISK IR, BEYER WS
T1 THe effect of morphine on the function of the normal and the pathologic kidney
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1928
FD June 30
VO 90
IS 26
SP 2082
OP 2083
DO 10.1001/jama.1928.02690530010004
UL http://dx.doi.org/10.1001/jama.1928.02690530010004
AB The advantages to the patient of the liberal use of morphine sulphate after operation are obvious, but many genito-urinary surgeons have hesitated to use it in sufficient quantity to control pain because of the possibility of interfering with the function of the kidney.Haines and Milliken,1 in their experiments, using indigo carmine as an indicator, concluded that a single dose of morphine and atropine did not impair the function of the kidney.The work herein reported was undertaken primarily for the purpose of determining the safety of administering morphine sulphate in quantities sufficient to insure comfort to patients who had been subjected to operations on organs of the genito-urinary tract, and who had some impairment of the kidney function. Preliminary to work on surgical patients, a series of nonsurgical patients with normal kidneys (as shown by the excretion of phenolsulphonphthalein and the estimation of nonprotein nitrogen of the blood)