RT Journal
A1 EGGLESTON C, HATCHER RA
T1 THe pharmacology of the local anesthetics
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1919
FD October 25
VO 73
IS 17
SP 1256
OP 1258
DO 10.1001/jama.1919.02610430004002
UL http://dx.doi.org/10.1001/jama.1919.02610430004002
AB Acute intoxication in man from the use of the local anesthetics is far more common than is indicated by the number of recorded cases. We undertook to investigate the causes of such intoxication, and sought to find means of avoiding it, or combating it when it arises. This investigation has included a study of the literature of the more important cases of human intoxication, and the performance of over 300 experiments on cats. The details of this work are published elsewhere,1 the present communication being limited to a short discussion of the more important facts brought to light, especially with reference to their bearing on the clinical problem.Nine of the local anesthetics were studied, and the maximum toxicity of each was determined by rapid intravenous injection into cats. The drugs used, the fatal dose of each, the concentrations of the solutions employed, and the relative toxicities of the