RT Journal
A1 Rieger JB
T1 "The administration of arsphenamin"
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1919
FD August 30
VO 73
IS 9
SP 710
OP 710
DO 10.1001/jama.1919.02610350058025
UL http://dx.doi.org/10.1001/jama.1919.02610350058025
AB To the Editor: 
    —In the letter by Director McCoy of the Hygienic Laboratory, "The Administration of Arsphenamin" (The Journal, July 12, 1919, p. 130), there appears the statement that when only one of several physicians using arsphenamin of the same batch "registers complaint as to the quality of the drug, and the others use it with satisfaction, there seems to be no other conclusion than that the mode of administration in the exceptional case was at fault."In such, case I believe there is at least one other justifiable conclusion: that arsphenamin, perhaps insufficiently dried, will in the course of six months or a year develop toxic by-products in the ampule, and that the amount present will vary with the length of time that elapses before the contents are used and perhaps according to the conditions under which it has been stored. Conceivably such a product may pass the biologic