RT Journal A1 ROSENOW EC, STURDIVANT BF T1 Studies in influenza and pneumonia: Iv. further results of prophylactic inoculations JF Journal of the American Medical Association JO Journal of the American Medical Association YR 1919 FD August 9 VO 73 IS 6 SP 396 OP 401 DO 10.1001/jama.1919.02610320020005 UL http://dx.doi.org/10.1001/jama.1919.02610320020005 AB To determine the value of vaccination against disease, it is essential that the disease shall be one which a relatively large number of persons will develop unless protected, and that it be accompanied by serious consequences. These conditions were amply fulfilled during the pandemic of influenza. Moreover, the vaccine should contain the killed bacteria that produce symptoms and which are at least contributory to the cause of death. We have attempted, so far as possible, to fulfil this requirement by making a careful bacteriologic study of the disease, and by incorporating into the vaccine the important bacteria isolated. The epidemic was severe, and the need and the demand for vaccination were great; a large number of cases were available for bacteriologic study and to supply the proper strains for the vaccine. Vaccinations in large numbers during the past ten years with bacteria belonging to the group found in influenza have