RT Journal
A1 McCoy GW
T1 THe administration of arsphenamin
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1919
FD May 10
VO 72
IS 19
SP 1386
OP 1387
DO 10.1001/jama.1919.02610190048021
UL http://dx.doi.org/10.1001/jama.1919.02610190048021
AB To the Editor: 
    —It appears that there is a lamentable want of care on the part of many physicians who administer arsphenamin as to the concentration of the drug used and the time required for administration.The Hygienic Laboratory receives many complaints in regard to untoward results from the administration of arsphenamin made by various American producers. When careful investigation is made it is almost invariably found that the drug has been used in a solution that is too concentrated, and that it has been administered too rapidly. We have reports of a dose of 0.4 gm. being given in a volume of as little as 25 c.c. and injected within thirty seconds. Such practice is abuse, not use, of a powerful therapeutic agent.If, in addition to the usual precautions as to the use of perfect ampules and neutralization, physicians would give the drug in concentration of not more