RT Journal
A1 Hoyne AL, Arkin HS, Sherman MJ
T1 TReatment of a severe case of epidemic meningitis by combined intravenous and intraspinal injections of antimeningococcus serum
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1919
FD January 4
VO 72
IS 1
SP 22
OP 23
DO 10.1001/jama.1919.26110010001008a
UL http://dx.doi.org/10.1001/jama.1919.26110010001008a
AB We report this case because of the rapidity with which the symptoms cleared up under the combined method of treatment:Harry T., aged 18, entered the Cook County Hospital, Aug. 25, 1918, in a state of delirium, with the history that, forty-eight hours previously, he had developed a severe headache followed by projectile vomiting and fever, and had been irrational for twenty-four hours.Physical examination revealed marked rigidity of the neck with retraction of the head, opisthotonos, eyes deviating to the right, all reflexes exaggerated, positive Kernig and Brudzinski signs, rectal temperature 102.8, and pulse, 90. He was very restless and delirious, and it required several assistants plus partial ether anesthesia to do a spinal puncture. The fluid, 30 c.c. of which was withdrawn, was highly turbid, under increased pressure, with a cell count of 21,200 per cubic millimeter. Smears showed numerous intracellular and extracellular gram-negative diplococci. Ross-Jones and Nonne