RT Journal A1 Dansinger ML, Schaefer EJ T1 LOw-fat diets and weight change JF JAMA JO JAMA YR 2006 FD January 4 VO 295 IS 1 SP 94 OP 95 DO 10.1001/jama.295.1.94 UL http://dx.doi.org/10.1001/jama.295.1.94 AB The Women's Health Initiative (WHI),2 of which the Dietary Modification Trial is one component,3 is one of the most outstanding achievements in clinical research history. The National Institutes of Health established the WHI in 1991 to address the most common causes of death, disability, and impaired quality of life in postmenopausal women. This multimillion-dollar, 15-year project, involving 161 808 women aged 50 through 79 years, was designed to address many of the inequities in women's health research and provide practical information to women and their physicians about hormone therapy, calcium/vitamin D supplements, dietary patterns, and prevention of heart disease, cancer, and osteoporosis.