RT Journal A1 Shear K, Frank E, Houck PR, Reynolds CF T1 Treatment of complicated grief: A randomized controlled trial JF JAMA JO JAMA YR 2005 FD June 1 VO 293 IS 21 SP 2601 OP 2608 DO 10.1001/jama.293.21.2601 UL http://dx.doi.org/10.1001/jama.293.21.2601 AB Context  Complicated grief is a debilitating disorder associated with important negative health consequences, but the results of existing treatments for it have been disappointing.Objective  To compare the efficacy of a novel approach, complicated grief treatment, with a standard psychotherapy (interpersonal psychotherapy).Design  Two-cell, prospective, randomized controlled clinical trial, stratified by manner of death of loved one and treatment site.Setting  A university-based psychiatric research clinic as well as a satellite clinic in a low-income African American community between April 2001 and April 2004.Participants  A total of 83 women and 12 men aged 18 to 85 years recruited through professional referral, self-referral, and media announcements who met criteria for complicated grief.Interventions  Participants were randomly assigned to receive interpersonal psychotherapy (n = 46) or complicated grief treatment (n = 49); both were administered in 16 sessions during an average interval of 19 weeks per participant.Main Outcome Measure  Treatment response, defined either as independent evaluator-rated Clinical Global Improvement score of 1 or 2 or as time to a 20-point or better improvement in the self-reported Inventory of Complicated Grief.Results  Both treatments produced improvement in complicated grief symptoms. The response rate was greater for complicated grief treatment (51%) than for interpersonal psychotherapy (28%; P = .02) and time to response was faster for complicated grief treatment (P = .02). The number needed to treat was 4.3.Conclusion  Complicated grief treatment is an improved treatment over interpersonal psychotherapy, showing higher response rates and faster time to response.