RT Journal A1 Hébert PC, Fergusson DA T1 DO transfusions get to the heart of the matter? JF JAMA JO JAMA YR 2004 FD October 6 VO 292 IS 13 SP 1610 OP 1612 DO 10.1001/jama.292.13.1610 UL http://dx.doi.org/10.1001/jama.292.13.1610 AB Over the last half-century, it has become well recognized that patients with cardiovascular diseases and, more specifically, ischemic heart disease may be adversely affected by anemia. This is because the myocardium consumes or extracts 60% to 75% of all oxygen delivered to the coronary circulation.1- 3 Such an elevated extraction of oxygen, termed extraction ratio, is unique to the coronary circulation. As a result, oxygen delivery to the myocardium can be augmented only by increasing blood flow or oxygen content.1