RT Journal A1 Knight JR T1 A 35-year-old physician with opioid dependence JF JAMA JO JAMA YR 2004 FD September 15 VO 292 IS 11 SP 1351 OP 1357 DO 10.1001/jama.292.11.1351 UL http://dx.doi.org/10.1001/jama.292.11.1351 AB Some time later, Dr L became ill with an upper respiratory tract infection. Again, he self-treated his symptoms, this time with a cough syrup containing hydrocodone that he obtained from his office sample closet. The hydrocodone improved not only his cough but also his mood, and he began to take it regularly to get through the day, even after his cough resolved. It allowed him to function at a level he perceived as higher than his normal baseline: he was productive, attentive, happy, and energized. He began requiring more and more of the hydrocodone to achieve these effects.