RT Journal A1 DeAngelis CD, Drazen JM, Frizelle FA, et al T1 Clinical trial registration: A statement from the international committee of medical journal editors JF JAMA JO JAMA YR 2004 FD September 15 VO 292 IS 11 SP 1363 OP 1364 DO 10.1001/jama.292.11.1363 UL http://dx.doi.org/10.1001/jama.292.11.1363 AB Altruism and trust lie at the heart of research on human subjects. Altruistic individuals volunteer for research because they trust that their participation will contribute to improved health for others and that researchers will minimize risks to participants. In return for the altruism and trust that make clinical research possible, the research enterprise has an obligation to conduct research ethically and to report it honestly. Honest reporting begins with revealing the existence of all clinical studies, even those that reflect unfavorably on a research sponsor's product.