RT Journal A1 Duggan C, Fontaine O, Pierce NF, et al T1 SCientific rationale for a change in the composition of oral rehydration solution JF JAMA JO JAMA YR 2004 FD June 2 VO 291 IS 21 SP 2628 OP 2631 DO 10.1001/jama.291.21.2628 UL http://dx.doi.org/10.1001/jama.291.21.2628 AB A critical factor in this reduction in diarrhea deaths has been the widespread adoption of oral rehydration solution (ORS) programs for the treatment and prevention of diarrhea-associated dehydration.6- 7 Indeed, ORS has been hailed as one of the most important medical advances of the past century,8 at least in part because of its simplicity, low cost, and remarkable ease of use.