RT Journal A1 Parker RA, Hartman EE T1 A 25-year-old woman with bipolar disorder, 1 year later JF JAMA JO JAMA YR 2001 FD November 28 VO 286 IS 20 SP 2594 OP 2594 DO 10.1001/jama.286.20.2594 UL http://dx.doi.org/10.1001/jama.286.20.2594 AB In April 2000, at Psychiatry Grand Rounds, Gary Sachs, MD, discussed the epidemiology, natural history, diagnosis, and treatment of bipolar disorder.1 Ms G, a 25-year-old woman, exhibited pressured speech, tangential thinking, and labile affect prior to her 2 psychiatric admissions. Due to her concern about weight gain with lithium carbonate, she was treated with divalproex and olanzapine. As an outpatient, Ms G was taking divalproex (750 mg, twice daily) and bupropion hydrochloride (150 mg, twice daily). She recognized the ongoing need for medications, but hoped to get off them over time. She wondered what other treatment modalities might be available to her.