RT Journal A1 Brundtland G T1 AChieving worldwide tobacco control JF JAMA JO JAMA YR 2000 FD August 9 VO 284 IS 6 SP 750 OP 751 DO 10.1001/jama.284.6.750 UL http://dx.doi.org/10.1001/jama.284.6.750 AB Fifty years ago, THE JOURNAL published 2 articles1- 2 that were among the first of what was to become a deluge of epidemiological studies linking tobacco use to adverse health outcomes. These early studies on tobacco and disease established the basis for assessing disease causality and led to the conclusion that tobacco use is directly responsible for more than 25 causes of death.3 In the last 2 decades, this epidemiological evidence for disease causation has been complemented by evidence of economic harm.