RT Journal
A1 Heemskerk-Gerritsen BM, Kriege M, Seynaeve C
T1 ASsociation of risk-reducing surgery with cancer risks and mortality in brca mutation carriers
JF JAMA
JO JAMA
YR 2010
FD December 22
VO 304
IS 24
SP 2695
OP 2696
DO 10.1001/jama.2010.1854
UL http://dx.doi.org/10.1001/jama.2010.1854
AB 
To the Editor:  Better understanding of the effects of risk-reducing surgery on cancer risks and mortality is extremely relevant for geneticists and oncologists aiming at optimized counseling of BRCA mutation carriers. Dr Domchek and colleagues1 provided clinical data regarding risk-reducing salpingo-oophorectomy (RRSO) in a large cohort of BRCA1 and BRCA2 mutation carriers, enabling investigation in women with and without a history of breast cancer separately. However, there are some issues that require consideration.