RT Journal
A1 Gitlin LN, Hauck WW, Winter L
T1 WEll-being of patients with dementia and their caregivers after a biobehavioral home-based intervention
JF JAMA
JO JAMA
YR 2010
FD December 8
VO 304
IS 22
SP 2482
OP 2484
DO 10.1001/jama.2010.1790
UL http://dx.doi.org/10.1001/jama.2010.1790
AB 
Because our only data before 4 months (the primary end point) were from baseline, our choices for managing missing data from dropouts were limited. We rejected last observation carried forward because of its biasing effect when both groups naturally change from baseline to follow-up. We did deviate from ITT in that families who missed follow-up assessments were not included. However, we retained the ITT principle; all study participants with follow-up data were included in analyses regardless of participation level. This approach is used in other large-scale multisite nonpharmacologic interventions with caregivers and dementia patients.1- 2