RT Journal
A1 Rotondi M, Magri F, Chiovato L
T1 RIsk of coronary heart disease and mortality for adults with subclinical hypothyroidism
JF JAMA
JO JAMA
YR 2010
FD December 8
VO 304
IS 22
SP 2481
OP 2482
DO 10.1001/jama.2010.1786
UL http://dx.doi.org/10.1001/jama.2010.1786
AB 
To the Editor: In their study, Dr Rodondi and colleagues1 addressed the issue of the relationship between subclinical hypothyroidism and coronary heart disease (CHD) or mortality. Previous large prospective cohort studies have provided conflicting results about this extensively studied association. In the study by Rodondi et al, an attempt to reduce the effects of several confounders (including age, sex, degree of thyroid stimulating hormone [TSH] elevation, and pre-existing cardiovascular disease) was performed.1 However, the finding of no association of risk with subclinical hypothyroidism for TSH concentration up to 10.0 mIU/L may be flawed because it did not provide information about the body mass index (BMI) of the patients diagnosed with subclinical hypothyroidism.