RT Journal A1 Psaty BM, Prentice RL T1 IMportance of blinding in randomized trials—reply JF JAMA JO JAMA YR 2010 FD November 17 VO 304 IS 19 SP 2127 OP 2128 DO 10.1001/jama.2010.1622 UL http://dx.doi.org/10.1001/jama.2010.1622 AB It is not clear how Strite and Stuart imagine that the balance between treatment groups resulting from randomization itself might be disrupted. Perhaps they have in mind allocation concealment, which is typically used to describe tamper-proof methods of randomization. Allocation concealment is different from whether the trial is conducted in an open or a blinded fashion, and it is important in all trials, open or blinded.