RT Journal A1 Friedrich MJ T1 PLatelets and lupus JF JAMA JO JAMA YR 2010 FD November 3 VO 304 IS 17 SP 1888 OP 1888 DO 10.1001/jama.2010.1518 UL http://dx.doi.org/10.1001/jama.2010.1518 AB The researchers found that platelets from patients experiencing flare-ups of SLE were abnormally activated compared with platelets from healthy individuals. The inappropriately activated platelets triggered an increase in levels of the protein CD154 that stimulated the production of interferons and caused inflammation in human and mouse cells.