RT Journal
A1 Friedrich MJ
T1 AUtoimmunity and arthritis
JF JAMA
JO JAMA
YR 2010
FD November 3
VO 304
IS 17
SP 1888
OP 1888
DO 10.1001/jama.2010.1517
UL http://dx.doi.org/10.1001/jama.2010.1517
AB 
Researchers from the University of Rochester in New York and collaborators from across the United States and China discovered that the protein subunit G alpha q (Gaq) is part of a signaling pathway that determines the fate of autoreactive B cells and prevents them from building up and mistakenly attacking the body's own tissues. They showed that in mice genetically modified to lack Gaq, these harmful B cells survive and cause rapid development of arthritis and other manifestations of autoimmune disease.