RT Journal A1 Oken E, Belfort MB T1 FIsh, fish oil, and pregnancy JF JAMA JO JAMA YR 2010 FD October 20 VO 304 IS 15 SP 1717 OP 1718 DO 10.1001/jama.2010.1541 UL http://dx.doi.org/10.1001/jama.2010.1541 AB Fish are a rich source of long-chain n-3 (omega-3) polyunsaturated fatty acids (PUFA), essential nutrients that have important structural and physiological roles in several body systems, including neurological, immune, and cardiovascular. Because humans cannot synthesize n-3 PUFA, these nutrients must be consumed in the diet. Conversion from the parent n-3 PUFA, α-linolenic acid, to the more biologically active long-chain n-3 PUFA, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), is inefficient and therefore consumption of some preformed long-chain n-3 PUFA is important for optimal health. In the United States and elsewhere, fish is the main dietary source of DHA and EPA.