RT Journal
A1 Kuehn BM
T1 TEstosterone trial halted
JF JAMA
JO JAMA
YR 2010
FD August 25
VO 304
IS 8
SP 846
OP 846
DO 10.1001/jama.2010.1196
UL http://dx.doi.org/10.1001/jama.2010.1196
AB 
The Testosterone in Older Men (TOM) trial randomized 209 men (average age, 74 years) with low testosterone levels and limited mobility to 6 months of therapy with either a testosterone gel or placebo to determine whether the therapy increased strength and the ability to walk and climb stairs (Basaria S et al. N Engl J Med. 2010;363[2]:109-122). The DSMB stopped the treatment phase of the TOM trial on December 31, 2009, after reviewing preliminary data that revealed that 23 of the 106 men who received testosterone experienced cardiovascular events (the risk was constant during the treatment period), including myocardial infarction, heart rhythm disturbances, and elevated blood pressure; only 5 of the 103 men in the placebo group experienced such events.