RT Journal A1 Nampiaparampil DE T1 Cancer pain: Assessment, diagnosis, and management JF JAMA JO JAMA YR 2010 FD June 23 VO 303 IS 24 SP 2529 OP 2533 DO 10.1001/jama.2010.848 UL http://dx.doi.org/10.1001/jama.2010.848 AB While most practitioners may be familiar with cancer-related pain as a composite entity, they may not be familiar with its different nociceptive and neuropathic components. After reading this text, they will be. The authors systematically define the different mechanisms by which cancer can cause pain and then provide a detailed analysis of each aspect of the problem. For example, they write that “Tumor involvement of the peripheral nervous system has many manifestations and can include lesions within the cerebrospinal fluid space, local invasion, compression of nerves, direct infiltration, perineural spread, and intraneural metastases.”