RT Journal
A1 Small PA, Morris J
T1 INfluenza vaccination of children and infection rates in the community
JF JAMA
JO JAMA
YR 2010
FD June 16
VO 303
IS 23
SP 2355
OP 2356
DO 10.1001/jama.2010.779
UL http://dx.doi.org/10.1001/jama.2010.779
AB 
To the Editor: The randomized study by Dr Loeb and colleagues1 of communities receiving either inactivated influenza vaccine or hepatitis A vaccine supports school-based influenza immunization and adds credence to a nationwide Japanese study that concluded that 1 life was saved for every 420 children immunized against influenza.2 The study by Loeb et al showed protection of community members against clinical illness, confirmed by real-time reverse transcriptase–polymerase chain reaction assay, but failed to show protection against infection as determined by hemagglutination inhibition titers. The authors speculated that “[o]ne possible explanation for the lack of significant differences in serologic outcomes is that the influenza vaccination may have attenuated infection that . . . rendered it subclinical but without preventing infection.”