RT Journal
A1 Hampton T
T1 PArkinson disease insights
JF JAMA
JO JAMA
YR 2010
FD June 2
VO 303
IS 21
SP 2129
OP 2129
DO 10.1001/jama.2010.685
UL http://dx.doi.org/10.1001/jama.2010.685
AB 
One gene encodes parkin, which adds ubiquitin molecules to other proteins to trigger their degradation; the second gene, PINK1 (PTEN-induced putative kinase 1), is involved with mitochondrial maintenance. Problems with ubiquitination and mitochondrial integrity are key factors in the pathogenesis of Parkinson disease.