RT Journal A1 DeRubeis RJ, Fournier JC, Fawcett J T1 DEpression severity and effect of antidepressant medications—reply JF JAMA JO JAMA YR 2010 FD April 28 VO 303 IS 16 SP 1596 OP 1599 DO 10.1001/jama.2010.510 UL http://dx.doi.org/10.1001/jama.2010.510 AB Elkin expresses skepticism about our suggestion that alternative outcome measures might reveal larger differences between antidepressants and placebos in mild and moderate cases, given that such measures did not produce such a pattern in her study. We note, however, recent findings suggesting that antidepressants yield benefits for patients that extend beyond depression symptoms.1