RT Journal
A1 Kuehn BM
T1 COcaine addiction
JF JAMA
JO JAMA
YR 2010
FD February 24
VO 303
IS 8
SP 722
OP 722
DO 10.1001/jama.2010.166
UL http://dx.doi.org/10.1001/jama.2010.166
AB 
Previous studies have demonstrated that repeated cocaine administration leads to persistent changes both in gene expression and in the structure of the nucleus accumbens of the brain. Now a multi-institutional team of scientists has demonstrated, through a series of experiments in mice, that repeated cocaine administration suppresses the activity of G9A, an enzyme that helps regulate whether genes are turned on or off (Maze I et al. Science. 2010;327[5962]:213-216).