RT Journal
A1 Edwards JL
T1 HOrmonal therapy for prostate cancer in men with heart disease
JF JAMA
JO JAMA
YR 2010
FD January 6
VO 303
IS 1
SP 32
OP 33
DO 10.1001/jama.2009.1930
UL http://dx.doi.org/10.1001/jama.2009.1930
AB 
Diabetes, unlike hypertension and hypercholesterolemia, is classified as a CAD risk equivalent, meaning that patients with diabetes have a risk comparable with nondiabetic patients with established CAD.2 Moreover, androgen suppression is associated with insulin resistance,3 possibly increasing the risk of both cardiac and noncardiac complications of diabetes. Because of this, patients with diabetes should be analyzed as a separate group, lest evidence of harm be diluted or obscured by benefit to lower-risk patients. In addition, diabetes and hypertension frequently coexist,4 so the risk calculated for patients with normotensive diabetes should not be considered representative of patients with diabetes in general.