RT Journal A1 Schaefer G, Emanuel EJ, Wertheimer A T1 PArticipating in biomedical research—reply JF JAMA JO JAMA YR 2009 FD November 25 VO 302 IS 20 SP 2200 OP 2202 DO 10.1001/jama.2009.1721 UL http://dx.doi.org/10.1001/jama.2009.1721 AB It is unclear whether there is disagreement between Dr Powell and colleagues and the view that people have a prima facie obligation to participate in research. Their principal argument is that those who do not benefit from research because of inequities in access to health care do not have an obligation to participate in research. But our public goods argument for an obligation to participate in research notes that this obligation holds “only if the burden of participation is less than the overall benefit of biomedical research to the individual.” Thus, if inequities preclude an individual from receiving benefits of research, then the prima facie obligation is outweighed.