RT Journal A1 Katz KA T1 PArticipating in biomedical research JF JAMA JO JAMA YR 2009 FD November 25 VO 302 IS 20 SP 2200 OP 2202 DO 10.1001/jama.2009.1718 UL http://dx.doi.org/10.1001/jama.2009.1718 AB Some research, such as the study presented in the article's opening vignette that investigates treatment for a difficult-to-treat chronic condition, addresses important clinical questions and therefore provides substantial value. Individuals ought to enroll in those studies.