RT Journal A1 Greene SM, Mazor KM, Gallagher TH T1 PArticipating in biomedical research JF JAMA JO JAMA YR 2009 FD November 25 VO 302 IS 20 SP 2200 OP 2202 DO 10.1001/jama.2009.1717 UL http://dx.doi.org/10.1001/jama.2009.1717 AB Coincidentally, the Special Communication and the Institute of Medicine report on comparative effectiveness research2 were published simultaneously. Comparative effectiveness research examines features of medicine that could be modified to improve care, such as different treatment options. But it has become increasingly apparent that the behaviors of those involved in health care organization and delivery also affect outcomes. Understanding of the myriad factors beyond individual therapeutic choices that affect patient health is still limited. Progress will require the cooperation of clinicians, including not only general support for research but also being participants in research on their role in the health care system.