RT Journal
A1 Rosenstein RS, Parra D
T1 BIomarkers for prediction of cardiovascular events
JF JAMA
JO JAMA
YR 2009
FD November 18
VO 302
IS 19
SP 2089
OP 2090
DO 10.1001/jama.2009.1637
UL http://dx.doi.org/10.1001/jama.2009.1637
AB 
When assessing the value of a biomarker within a well-calibrated system, the C statistic of the receiver operating characteristic curve is used to evaluate its potential incremental benefit over other risk factors or panels. In the study by Melander et al, as well as in past studies,2 the results of this approach have been disappointing because of the very modest improvement compared with most traditional risk markers. The more correlated a novel marker is with traditional risk factors, the less its addition may improve discrimination.3