RT Journal
A1 Califf RM
T1 CLinical research sites—the underappreciated component of the clinical research system
JF JAMA
JO JAMA
YR 2009
FD November 11
VO 302
IS 18
SP 2025
OP 2027
DO 10.1001/jama.2009.1655
UL http://dx.doi.org/10.1001/jama.2009.1655
AB 
Recent efforts have aimed at improving research coordination and data analysis through centralized organization and application of technology, while leveraging databases and registries has achieved an exalted status in comparative effectiveness research. Less attention, however, has been paid to issues surrounding prospective research in the patient care setting, and the fundamental unit of clinical research—the clinical research site (CRS)—has been particularly neglected. Despite their vital contributions, CRSs are largely underappreciated in the clinical research enterprise, toiling in obscurity while others reap the rewards of their efforts.