RT Journal
A1 Schwahn C, Grabe H
T1 GEne-environment interactions and depression
JF JAMA
JO JAMA
YR 2009
FD November 4
VO 302
IS 17
SP 1859
OP 1862
DO 10.1001/jama.2009.1577
UL http://dx.doi.org/10.1001/jama.2009.1577
AB 
To the Editor: In their meta-analysis, Dr Risch and colleagues1 reported on gene-environment interactions in depressive disorders, focusing on the interaction between the serotonin transporter promoter polymorphism and life events. They stated that “the samples, study designs, measures, and analyses were highly divergent across studies, thereby limiting the comparability of the studies and their evidence regarding replication.” However, the authors did not address 2 other problems arising from the methodology of their meta-analysis.